TGF-β1 and IGF-I gene variations in type 1 diabetes microangiopathic complications

@inproceedings{Bazzaz2014TGF1AI,
  title={TGF-β1 and IGF-I gene variations in type 1 diabetes microangiopathic complications},
  author={Javad Tavakkoly Bazzaz and Mahsa Mohammad Amoli and Zahra Taheri and Bagher Larijani and Vera Pravica and Ian V. Hutchinson},
  booktitle={Journal of diabetes and metabolic disorders},
  year={2014}
}
BACKGROUND Growth factors are generally believed to have a perpetuating role in the development of diabetic complications, However there is ample of evidence of a protective or therapeutic potential for some of them. IGF-I, according to some reports, may contribute to complication development, although a protective role for IGF-I has been claimed for all late diabetic complications, making it an exception among growth factors. Transforming growth factor (TGF)-β1 as a pleiotropic cytokine is a… CONTINUE READING