TGF-β1 Suppresses IL-33-Induced Mast Cell Function.

  title={TGF-β1 Suppresses IL-33-Induced Mast Cell Function.},
  author={Victor S Ndaw and Daniel Abebayehu and Andrew J. Spence and Patrick A Paez and Elizabeth Motunrayo Kolawole and Marcela T. Taruselli and Heather L. Caslin and Alena P. Chumanevich and Anuya Paranjape and Bianca Baker and Brian O. Barnstein and Tamara T. Haque and Kasalina N. Kiwanuka and Carole A Oskeritzian and John Jake Ryan},
  journal={Journal of immunology},
  volume={199 3},
TGF-β1 is involved in many pathological conditions, including autoimmune disorders, cancer, and cardiovascular and allergic diseases. We have previously found that TGF-β1 can suppress IgE-mediated mast cell activation of human and mouse mast cells. IL-33 is a member of the IL-1 family capable of inducing mast cell responses and enhancing IgE-mediated activation. In this study, we investigated the effects of TGF-β on IL-33-mediated mast cell activation. Bone marrow-derived mast cells cultured in… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS