TGF-β upregulates miR-181a expression to promote breast cancer metastasis.

  title={TGF-β upregulates miR-181a expression to promote breast cancer metastasis.},
  author={Molly A Taylor and Khalid Sossey-Alaoui and Cheryl L. Thompson and David Danielpour and William P. Schiemann},
  journal={The Journal of clinical investigation},
  volume={123 1},
Late-stage breast cancer metastasis is driven by dysregulated TGF-β signaling, but the underlying molecular mechanisms have not been fully elucidated. We attempted to recapitulate tumor and metastatic microenvironments via the use of biomechanically compliant or rigid 3D organotypic cultures and combined them with global microRNA (miR) profiling analyses to identify miRs that were upregulated in metastatic breast cancer cells by TGF-β. Here we establish miR-181a as a TGF-β-regulated "metastamir… CONTINUE READING
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