TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice.

Abstract

Hassall's corpuscles are concentric clusters of keratinized epithelial cells located within the thymic medulla of humans and guinea pigs but are scant in mouse and rat. They are considered to be the terminally differentiated stages of medullary thymic epithelial cells (mTECs) but the mechanisms of their origin are unclear. We have previously deleted the TGF… (More)
DOI: 10.1093/intimm/dxt026

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