TGF-β signaling in vascular biology and dysfunction

  title={TGF-β signaling in vascular biology and dysfunction},
  author={Marie-Jos{\'e} Goumans and Zhen Liu and Peter ten Dijke},
  journal={Cell Research},
Transforming growth factor (TGF)-β family members are multifunctional cytokines that elicit their effects on cells, including endothelial and mural cells, via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. Knock-out mouse models for TGF-β family signaling pathway components have revealed their critical importance in proper yolk sac angiogenesis. Genetic studies in humans have linked mutations in these signaling components to specific… CONTINUE READING


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