TGF-β signaling in liver and gastrointestinal cancers.

Abstract

Transforming Growth Factor-β (TGF-β) plays crucial and complex roles in liver and gastrointestinal cancers. These include a multitude of distinct functions, such as maintaining stem cell homeostasis, promoting fibrosis, immune modulating, as a tumor suppressor and paradoxically, as a tumor progressor. However, key mechanisms for the switches responsible for… (More)
DOI: 10.1016/j.canlet.2016.03.033

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