TGF-β-related mechanisms of bone destruction in multiple myeloma.

  title={TGF-β-related mechanisms of bone destruction in multiple myeloma.},
  author={Toshio Matsumoto and Masahiro Abe},
  volume={48 1},
In destructive bone lesions of multiple myeloma (MM), osteoclastic bone resorption is enhanced, while bone formation is suppressed with impaired osteoblast differentiation from their progenitor cells. As a result, a strong negative balance in bone turnover develops in MM bone lesions. The suppression of bone formation is mainly due to a secretion of Wnt… CONTINUE READING