TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance.

@article{Lee2014TGFproducingRB,
  title={TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance.},
  author={Kang Mi Lee and Ryan T. Stott and Gaoping Zhao and Julie Soohoo and Wei Xiong and Moh Moh Lian and Lindsey Fitzgerald and Shuai Shi and Elsie Akrawi and Ji Lei and Shaoping Deng and H. -Sh. Yeh and James F. Markmann and J i-Young Kim},
  journal={European journal of immunology},
  year={2014},
  volume={44 6},
  pages={
          1728-36
        }
}
Regulatory B (Breg) cells have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined anti-T cell immunoglobulin domain and mucin domain-1 and anti-CD45RB antibody treatment results in tolerance to full MHC-mismatched islet allografts in mice by generating Breg cells that are necessary for tolerance. Breg cells are antigen-specific and are capable of transferring tolerance to untreated, transplanted animals. Here, we… CONTINUE READING
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