TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

  title={TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway},
  author={S{\'e}bastien Viel and Antoine Marçais and Fernando Souza-Fonseca Guimaraes and Rois{\'i}n M Loftus and Jessica Rabilloud and Morgan Grau and Sophie Degouve and Sophia Djebali and Am{\'e}lien Sanlaville and Emily Charrier and Jacques Bienvenu and Julien C. Marie and Christophe Caux and Jacqueline Marvel and Liam Town and Nicholas D Huntington and Laurent Bartholin and David K Finlay and Mark J Smyth and Thierry Walzer},
  journal={Science Signaling},
Transforming growth factor–β (TGF-β) is a major immunosuppressive cytokine that maintains immune homeostasis and prevents autoimmunity through its antiproliferative and anti-inflammatory properties in various immune cell types. We provide genetic, pharmacologic, and biochemical evidence that a critical target of TGF-β signaling in mouse and human natural killer (NK) cells is the serine and threonine kinase mTOR (mammalian target of rapamycin). Treatment of mouse or human NK cells with TGF-β in… CONTINUE READING
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