TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase

  title={TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase},
  author={Chuan-Wei Jang and C Chen and Chun-Chieh Chen and Jia-Yun Chen and Yi-Hsien Su and R H Chen},
  journal={Nature Cell Biology},
Transforming growth factor-β (TGF-β) and TGF-β-related factors induce apoptosis in a variety of tissues; however, the mechanism underlying this induction is largely unknown. Here, we demonstrate that TGF-β induces the expression of the death-associated protein kinase (DAP-kinase) as an immediate early response in cells that undergo apoptosis in response to TGF-β. DAP-kinase is a positive mediator of apoptosis induced by certain cytokines and oncogenes. We show that the DAP-kinase promoter is… CONTINUE READING