TGF-β-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms.

@article{Scharenberg2014TGFinducedDI,
  title={TGF-β-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms.},
  author={Matthias Alexander Scharenberg and Benjamin E. Pippenger and Ragna Sack and Dominik Zingg and Jacqueline Ferralli and Susanne H Schenk and Ivan Martin and Ruth Chiquet-Ehrismann},
  journal={Journal of cell science},
  year={2014},
  volume={127 Pt 5},
  pages={1079-91}
}
Cellular transformation into myofibroblasts is a central physiological process enabling tissue repair. Its deregulation promotes fibrosis and carcinogenesis. TGF-β is the main inducer of the contractile gene program that drives myofibroblast differentiation from various precursor cell types. Crucial regulators of this transcriptional program are serum response factor (SRF) and its cofactor MKL1 (also known as MRTF-A). However, the exact mechanism of the crosstalk between TGF-β signaling and… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
14 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…