TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease

  title={TGF-$\beta$-induced EMT: mechanisms and implications for fibrotic lung disease},
  author={Brigham C. Willis and Zea Borok},
  journal={American Journal of Physiology-lung Cellular and Molecular Physiology},
  • B. WillisZ. Borok
  • Published 1 September 2007
  • Medicine, Biology
  • American Journal of Physiology-lung Cellular and Molecular Physiology
Epithelial-mesenchymal transition (EMT), a process whereby fully differentiated epithelial cells undergo transition to a mesenchymal phenotype giving rise to fibroblasts and myofibroblasts, is increasingly recognized as playing an important role in repair and scar formation following epithelial injury. The extent to which this process contributes to fibrosis following injury in the lung is a subject of active investigation. Recently, it was demonstrated that transforming growth factor (TGF… 

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