TGF-β in cancer and bone: implications for treatment of bone metastases.

Abstract

Bone metastases are common in patients with advanced breast, prostate and lung cancer. Tumor cells co-opt bone cells to drive a feed-forward cycle which disrupts normal bone remodeling to result in abnormal bone destruction or formation and tumor growth in bone. Transforming growth factor-beta (TGF-β) is a major bone-derived factor, which contributes to… (More)
DOI: 10.1016/j.bone.2010.08.004

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Cite this paper

@article{Jurez2011TGFIC, title={TGF-β in cancer and bone: implications for treatment of bone metastases.}, author={Patricia Ju{\'a}rez and Theresa A. Guise}, journal={Bone}, year={2011}, volume={48 1}, pages={23-9} }