TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration

@inproceedings{Tosi2018TGFCA,
  title={TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration},
  author={Gian Marco Tosi and Giovanni Neri and Elena Caldi and Fiorella Fusco and Tommaso Bacci and Antonio Tarantello and Elisabetta Nuti and Davide Marigliani and Stefano Baiocchi and Claudio Traversi and Marcella Barbarino and Chiara M Eandi and Barbara Parolini and Lucia Mundo and Annalisa Santucci and Maurizio Orlandini and Federico Galvagni},
  booktitle={Scientific Reports},
  year={2018}
}
Controversy still exists regarding the role of the TGF-β in neovascular age-related macular degeneration (nAMD), a major cause of severe visual loss in the elderly in developed countries. Here, we measured the concentrations of active TGF-β1, TGF-β2, and TGF-β3 by ELISA in the aqueous humor of 20 patients affected by nAMD, who received 3 consecutive monthly intravitreal injections of anti-VEGF-A antibody. Samples were collected at baseline (before the first injection), month 1 (before the… CONTINUE READING
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