TGF-β co-opts STAT3-STAT4 signaling to promote human T follicular helper cell differentiation

Abstract

Understanding the developmental mechanisms of T follicular helper (TFH) cells in humans is a highly relevant topic to clinic. However, factors that drive human CD4+ helper T (TH) cell differentiation program towards TFH cells remain largely undefined. Here we show that TGF-β provides critical additional signals for the transcription factors STAT3 and STAT4… (More)

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