TGF-β and Regulatory T Cell in Immunity and Autoimmunity

  title={TGF-β and Regulatory T Cell in Immunity and Autoimmunity},
  author={Yisong Y. Wan and Richard A Flavell},
  journal={Journal of Clinical Immunology},
The immune response is controlled by several inhibitory mechanisms. These mechanisms include regulatory T cells, which exist in multiple classes. Notable among these are Foxp3-expressing regulatory T cells (Treg), NKT cells, and Tr1 cells. Common to these mechanisms are inhibitory cytokines such as interleukin-10 and transforming growth factor-beta (TGF-β). TGF-β and Foxp3-expressing Treg cells are critical in maintaining self-tolerance and immune homeostasis. The immune suppressive functions… CONTINUE READING