TGF-β activates Akt kinase via a microRNA-dependent amplifying circuit targeting PTEN

@inproceedings{Kato2009TGFAA,
  title={TGF-β activates Akt kinase via a microRNA-dependent amplifying circuit targeting PTEN},
  author={Mitsuo Kato and Sumanth Putta and Mei Wang and Hang Yuan and Linda L. Lanting and Indu Nair and Amanda Gunn and Yoshimi Nakagawa and Hitoshi Shimano and Ivan T Todorov and John J. Rossi and Rama Natarajan},
  booktitle={Nature Cell Biology},
  year={2009}
}
Akt kinase is activated by transforming growth factor-β1 (TGF-β) in diabetic kidneys, and has important roles in fibrosis, hypertrophy and cell survival in glomerular mesangial cells. However, the mechanisms of Akt activation by TGF-β are not fully understood. Here we show that TGF-β activates Akt in glomerular mesangial cells by inducing the microRNAs (miRNAs) miR-216a and miR-217, both of which target PTEN (phosphatase and tensin homologue), an inhibitor of Akt activation. These miRNAs are… CONTINUE READING
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target recognition and regulatory functions

  • Bartel, D. P. MicroRNAs
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  • 2009

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