TGF-β Tumor Suppression through a Lethal EMT

  title={TGF-β Tumor Suppression through a Lethal EMT},
  author={Charles J. David and Yun-Han Huang and M. -S. Chen and Jie Su and Yilong Zou and Nabeel Bardeesy and Christine A Iacobuzio-Donahue and Joan Massagu{\'e}},
TGF-β signaling can be pro-tumorigenic or tumor suppressive. We investigated this duality in pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers, exhibits frequent inactivation of the TGF-β mediator Smad4. We show that TGF-β induces an epithelial-mesenchymal transition (EMT), generally considered a pro-tumorigenic event. However, in TGF-β-sensitive PDA cells, EMT becomes lethal by converting TGF-β-induced Sox4 from an enforcer of tumorigenesis into a promoter of… CONTINUE READING