TGF-β Signaling in Cancer.

  title={TGF-β Signaling in Cancer.},
  author={Viqar Syed},
  journal={Journal of cellular biochemistry},
  volume={117 6},
The transforming growth factor-β (TGF-β) is a family of structurally related proteins that comprises of TGF-β, activins/inhibins, and bone morphogenic proteins (BMPs). Members of the TGF-β family control numerous cellular functions including proliferation, apoptosis, differentiation, epithelial-mesenchymal transition (EMT), and migration. The first identified member, TGF-β is implicated in several human diseases, such as vascular diseases, autoimmune disorders, and carcinogenesis. Activation of… CONTINUE READING