TGF-β 1 Promotes Osteosarcoma Cell Migration and Invasion Through the miR-143-Versican Pathway

@inproceedings{Chenga2014TGF1P,
  title={TGF-β 1 Promotes Osteosarcoma Cell Migration and Invasion Through the miR-143-Versican Pathway},
  author={Fengfeng Lia Shaohua Lib Tao Chenga},
  year={2014}
}
  • Fengfeng Lia Shaohua Lib Tao Chenga
  • Published 2014
Background & Aims: TGF-β1 is an abundant cytokine present in the tumour microenvironment. It has been shown to trigger versican expression in human osteosarcoma cells, which may account for the metastatic potential of these cells. However, the underlying mechanism of TGF-β1-mediated metastasis remains unclear. The aim of this study was to evaluate the roles of versican in TGF-β1-induced osteosarcoma cell migration and invasion. Methods: Sixty paired osteosarcoma tumour tissues and adjacent… CONTINUE READING
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