TGF-β , Smad 3 and the process of progressive fibrosis

Abstract

Transient adenovirus-mediated gene transfer of active TGF-β1 (transforming growth factor-β1) induces severe and progressive fibrosis in rodent lung without apparent inflammation. Alternatively, transfer of IL-1β (interleukin 1β) induces marked tissue injury and inflammation, which develops into progressive fibrosis, associated with an increase in TGF-β1… (More)

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