TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

  title={TGF-{\ss} Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia},
  author={Neil A. Bhowmick and Anna Chytil and David Plieth and Agnieszka E. Gorska and Nancy Dumont and Scott B. Shappell and M. Kay Washington and Eric G. Neilson and Harold L Moses},
  pages={848 - 851}
Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor–β (TGF-β) signaling in such epithelial-mesenchymal interactions was determined by conditional inactivation of the TGF-β type II receptor gene in mouse fibroblasts (Tgfbr2fspKO). The loss of TGF-β responsiveness in fibroblasts resulted in intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach, both associated with an… 

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