TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

@article{Bhowmick2004TGFSI,
  title={TGF-{\ss} Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia},
  author={Neil A. Bhowmick and Anna Chytil and David Plieth and Agnieszka E. Gorska and Nancy Dumont and Scott B. Shappell and M. Kay Washington and Eric G. Neilson and Harold L Moses},
  journal={Science},
  year={2004},
  volume={303},
  pages={848 - 851}
}
Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor–β (TGF-β) signaling in such epithelial-mesenchymal interactions was determined by conditional inactivation of the TGF-β type II receptor gene in mouse fibroblasts (Tgfbr2fspKO). The loss of TGF-β responsiveness in fibroblasts resulted in intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach, both associated with an… 
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TGF-β Signaling in Fibroblastic Cells and Oncogenesis

Reports suggest stromal TGF-β responsivity is involved in the initiation, progression and metastasis of cancer in a tissue specific manner.

TGF-β Signaling in Fibroblasts Regulates Tumor Initiation and Progression in Adjacent Epithelia

The literature suggests that the T GF-β response by fibroblasts and fibroblast production of TGF-β ligands can suppress or promote adjacent carcinoma progression depending upon the context of stimulation.

TGF-β Signaling Alterations in Neoplastic and Stromal Cells

Transforming growth factor beta (TGF-β) plays an central role in cell homeostasis and inherited mutations in the TGFB1 gene cause Camurati-Engelmann disease, a condition characterized by hyperostosis…

Cancer-Associated Fibroblasts and the Role of TGF-β

Experimental evidence on the important role of TGF-β in fibroblast-epithelial interaction, as obtained from in vitro studies and from animal models is presented.

TGF-β and Stromal Influences Over Local Tumor Invasion

It is likely that a better characterization of the role of TGF-β in the crosstalk between stromal and malignant cells will unravel novel therapeutic options and promote tumor growth at late stages of carcinogenesis.

Role of the Adjacent Stroma Cells in Prostate Cancer Development and Progression: Synergy between TGF-β and IGF Signaling

A continuous input from TGF-β and IGF in the tumor microenvironment will result in cancer progression and understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.

Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment

How a core property of TGF-β, namely its ability to change cell differentiation, leads to the transition of epithelial cells, endothelial cells and fibroblasts to a myofibroblastoid phenotype, changes differentiation and polarization of immune cells, and induces metabolic reprogramming of cells are discussed.

Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.

In vivo, tissue recombination of fibroblasts overexpressing TGF-β1 and SDF1/CXCL12 not only induced transformation of BPH1 cells, but also promoted a robust growth of highly invasive cells, similar to effects produced by CAFs.

BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis

These findings reveal a complex cross-talk between epithelial cells and the stroma, wherein Smad4 is required to elicit squamous cell carcinomas in the forestomach of mice with TGFBR2-deficient stromal cells.

Stromal Modulators of TGF-β in Cancer

The present review highlights the present understanding of how stroma modulates TGF-β activity in human cancers and highlights the need to understand the complex interplay between the T GF-β signaling network and these stromal proteins.
...

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