TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
@article{Bhowmick2004TGFSI, title={TGF-{\ss} Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia}, author={N. Bhowmick and A. Chytil and D. Plieth and Agnieszka E. Gorska and N. Dumont and S. Shappell and M. Washington and E. Neilson and H. Moses}, journal={Science}, year={2004}, volume={303}, pages={848 - 851} }
Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor–β (TGF-β) signaling in such epithelial-mesenchymal interactions was determined by conditional inactivation of the TGF-β type II receptor gene in mouse fibroblasts (Tgfbr2fspKO). The loss of TGF-β responsiveness in fibroblasts resulted in intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach, both associated with an… Expand
Topics from this paper
1,175 Citations
TGF-β Signaling in Fibroblasts Regulates Tumor Initiation and Progression in Adjacent Epithelia
- Biology
- 2011
- 1
Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.
- Biology, Medicine
- Cancer research
- 2011
- 153
- PDF
Role of the Adjacent Stroma Cells in Prostate Cancer Development and Progression: Synergy between TGF-β and IGF Signaling
- Biology, Medicine
- BioMed research international
- 2014
- 15
- PDF
BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis
- Chemistry, Medicine
- Molecular Cancer Research
- 2018
- 3
- Highly Influenced
- PDF
Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical Determinant
- Chemistry, Medicine
- Cell reports
- 2019
- 11
Transforming growth factor-beta signaling in skin: stromal to epithelial cross-talk.
- Biology, Medicine
- The Journal of investigative dermatology
- 2009
- 25
References
SHOWING 1-10 OF 20 REFERENCES
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.
- Biology, Medicine
- Genes & development
- 1996
- 672
- PDF
Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: in vitro analysis of tumor-stromal interactions.
- Biology, Medicine
- Cancer research
- 1997
- 325
- PDF
Binding of transforming growth factor-beta to cell surface proteins varies with cell type.
- Biology, Medicine
- Molecular endocrinology
- 1989
- 144
- PDF
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction.
- Biology, Medicine
- Physiological reviews
- 1996
- 739
Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction
- Biology, Medicine
- Nature Genetics
- 1995
- 1,000
Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor
- Biology, Medicine
- Journal of cellular physiology
- 1998
- 26
Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.
- Biology, Medicine
- Cancer research
- 2000
- 516
- PDF
Intrauterine transplantation of rat basal cell carcinoma as a model for reconversion of malignant to benign growth.
- Biology, Medicine
- Cancer research
- 1977
- 117
Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo.
- Biology, Medicine
- Development
- 1991
- 495