TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.

@article{Frutkin2009TGFbeta1LP,
  title={TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.},
  author={Andrew D. Frutkin and Goro Otsuka and April S. Stempien-Otero and Casilde Sesti and Liang Du and Mia Jaffe and Hel{\'e}n L. Dichek and Caroline J. Pennington and Dylan R W Edwards and Madeline Nieves-Cintr{\'o}n and Daniel Minter and Michael Preusch and Jie Hu and Julien C. Marie and David A. Dichek},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2009},
  volume={29 9},
  pages={1251-7}
}
OBJECTIVE Impairment of transforming growth factor (TGF)-beta1 signaling accelerates atherosclerosis in experimental mice. However, it is uncertain whether increased TGF-beta1 expression would retard atherosclerosis. The role of TGF-beta1 in aneurysm formation is also controversial. We tested whether overexpression of active TGF-beta1 in hyperlipidemic mice affects atherogenesis and aortic dilation. METHODS AND RESULTS We generated apolipoprotein E-null mice with transgenes that allow… CONTINUE READING

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Localization of TGF-beta signaling intermediates Smad2, 3, 4, and 7 in developing and mature human and mouse kidney.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society • 2007

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