TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT

@article{Zhuang2015TGF1SB,
  title={TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT},
  author={J. Zhuang and Q. Lu and B. Shen and Xiaojing Huang and L. Shen and X. Zheng and Ruimin Huang and Jun Yan and H. Guo},
  journal={Scientific Reports},
  year={2015},
  volume={5}
}
  • J. Zhuang, Q. Lu, +6 authors H. Guo
  • Published 2015
  • Biology, Medicine
  • Scientific Reports
  • Urinary bladder cancer (UBC) patients at muscle invasive stage have poor clinical outcome, due to high propensity for metastasis. Cancer-associated fibroblasts (CAFs), one of the principal constituents of the tumor stroma, play an important role in tumor development. However, it is unclear whether CAFs from UBC induce cell invasion and which signaling pathway is involved. Herein, we found that conditional medium from UBC CAFs (CAF-CM) enhanced the invasion of UBC cells. CAF-CM induced the… CONTINUE READING
    133 Citations
    Snail1-dependent cancer-associated fibroblasts induce epithelial-mesenchymal transition in lung cancer cells via exosomes.
    • J. You, M. Li, +4 authors C. Hu
    • Medicine
    • QJM : monthly journal of the Association of Physicians
    • 2019
    • 10
    • PDF
    Cancer-associated fibroblasts enhance metastatic potential of lung cancer cells through IL-6/STAT3 signaling pathway
    • 40
    • Highly Influenced
    • PDF
    A novel stromal lncRNA signature reprograms fibroblasts to promote the growth of oral squamous cell carcinoma via LncRNA-CAF/interleukin-33
    • 49
    • PDF
    TGFβ1 in fibroblasts-derived exosomes promotes epithelial-mesenchymal transition of ovarian cancer cells
    • 35
    • PDF
    Cancer-associated fibroblast-derived exosomal miR-382-5p promotes the migration and invasion of oral squamous cell carcinoma
    • 14
    • PDF

    References

    SHOWING 1-10 OF 61 REFERENCES
    TGF-β–Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12
    • 303
    • PDF
    Twist1 is a key regulator of cancer-associated fibroblasts.
    • 75
    • PDF
    Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.
    • 200
    • PDF