TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer

@inproceedings{Zhuang2017TGF1PG,
  title={TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer},
  author={Junlong Zhuang and L. R. Shen and Lin Yang and Xiaojing Huang and Qun Lu and Yangyan Cui and Xi Emily Zheng and Xiaozhi Zhao and Dianzheng Zhang and Ruimin Huang and Hongqian Guo and Jun Biao Yan},
  booktitle={Theranostics},
  year={2017}
}
High tumor recurrence is frequently observed in patients with urinary bladder cancers (UBCs), with the need for biomarkers of prognosis and drug response. Chemoresistance and subsequent recurrence of cancers are driven by a subpopulation of tumor initiating cells, namely cancer stem-like cells (CSCs). However, the underlying molecular mechanism in chemotherapy-induced CSCs enrichment remains largely unclear. In this study, we found that during gemcitabine treatment lncRNA-Low Expression in… CONTINUE READING
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