TGFβ1 Leu10Pro polymorphism contributes to the development of prostate cancer: evidence from a meta-analysis

  title={TGFβ1 Leu10Pro polymorphism contributes to the development of prostate cancer: evidence from a meta-analysis},
  author={Q. Cai and Y. Tang and M. Zhang and Zhiqun Shang and G. Li and J. Tian and N. Jiang and Changyi Quan and Y. Niu},
  journal={Tumor Biology},
  • Q. Cai, Y. Tang, +6 authors Y. Niu
  • Published 2013
  • Medicine
  • Tumor Biology
  • Transforming growth factor-β1 (TGFβ1) plays a significant role in regulating cellular proliferation and apoptosis. A large number of studies related to the association between TGFβ1 Leu10Pro polymorphism and prostate cancer (PC) risk, but get conflicting results. We performed a meta-analysis based on six studies, assessing the strength of the association using odds ratios (OR) with 95 % confidence intervals (CI). Overall, our evidence has indicated that TGFβ1 Leu10Pro polymorphism had… CONTINUE READING
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