TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

@article{Cui1996TGF1IT,
  title={TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice},
  author={Wei Cui and Deborah J. Fowlis and Sheila Bryson and Elizabeth Duffie and Hazel Ireland and Allan Balmain and Rosemary J. Akhurst},
  journal={Cell},
  year={1996},
  volume={86},
  pages={531-542}
}
TGFbeta1 has been implicated in cell cycle control and carcinogenesis. To address the exact function of TGFbeta1 in skin carcinogenesis in vivo, mice with TGFbeta1 expression targeted to keratinocytes were subjected to long-term chemical carcinogenesis treatment. TGFbeta1 showed biphasic action during multistage skin carcinogenesis, acting early as a tumor suppressor but later enhancing the malignant phenotype. The transgenics were more resistant to induction of benign skin tumors than controls… CONTINUE READING
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