TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells.

@article{Wang2016TGFSR,
  title={TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells.},
  author={Lihui Wang and Xirui Li and Wenhao Huang and Tiancheng Zhou and Haitao Wang and Aiping Lin and Andrew P Hutchins and Zhenghui Su and Qianyu Chen and Duanqing Pei and Guangjin Pan},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={22484}
}
Human urine cells (HUCs) can be reprogrammed into neural progenitor cells (NPCs) or induced pluripotent stem cells (iPSCs) with defined factors and a small molecule cocktail, but the underlying fate choice remains unresolved. Here, through sequential removal of individual compound from small molecule cocktail, we showed that A8301, a TGFβ signaling… CONTINUE READING