TGFβ signaling in cartilage development and maintenance.

  title={TGFβ signaling in cartilage development and maintenance.},
  author={Weiguang Wang and Diana Rigueur and Karen M Lyons},
  journal={Birth defects research. Part C, Embryo today : reviews},
  volume={102 1},
Members of the transforming growth factor beta (TGFβ) superfamily of secreted factors play essential roles in nearly every aspect of cartilage formation and maintenance. However, the mechanisms by which TGFβs transduce their effects in cartilage in vivo remain poorly understood. Mutations in several TGFβ family members, their receptors, extracellular modulators, and intracellular transducers have been described, and these usually impact the development of the cartilaginous skeleton. Furthermore… CONTINUE READING
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