TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma.

@article{Gern2021TGFRE,
  title={TGF$\beta$ restricts expansion, survival, and function of T cells within the tuberculous granuloma.},
  author={Benjamin H Gern and Kristin N. Adams and Courtney R Plumlee and Caleb R. Stoltzfus and Laila Shehata and Albanus O. Moguche and Kathleen Busman-Sahay and Scott G Hansen and Michael K. Axthelm and L. Picker and Jacob D. Estes and Kevin B. Urdahl and Michael Y. Gerner},
  journal={Cell host \& microbe},
  year={2021}
}
CD4 T cell effector function is required for optimal containment of Mycobacterium tuberculosis (Mtb) infection. IFNɣ produced by CD4 T cells is a key cytokine that contributes to protection. However, lung-infiltrating CD4 T cells have a limited ability to produce IFNɣ, and IFNɣ plays a lesser protective role within the lung than at sites of Mtb dissemination. In a murine infection model, we observed that IFNɣ production by Mtb-specific CD4 T cells is rapidly extinguished within the granuloma… 
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