TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate.

@article{Iwata2014TGFRE,
  title={TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate.},
  author={Jun-ichi Iwata and Akiko Suzuki and Toshiaki Yokota and Tuong Vinh Ho and Richard C Pelikan and Mark Urata and Pedro A. Sanchez-Lara and Yang Chai},
  journal={Development},
  year={2014},
  volume={141 4},
  pages={909-17}
}
Clefting of the soft palate occurs as a congenital defect in humans and adversely affects the physiological function of the palate. However, the molecular and cellular mechanism of clefting of the soft palate remains unclear because few animal models exhibit an isolated cleft in the soft palate. Using three-dimensional microCT images and histological reconstruction, we found that loss of TGFβ signaling in the palatal epithelium led to soft palate muscle defects in Tgfbr2(fl/fl);K14-Cre mice… CONTINUE READING

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