TGFβ ligands promote the initiation of retinal ganglion cell dendrites in vitro and in vivo

@article{Hocking2008TGFLP,
  title={TGF$\beta$ ligands promote the initiation of retinal ganglion cell dendrites in vitro and in vivo
},
  author={Jennifer C. Hocking and Carrie Lynn Hehr and Ruoh-Yeng Chang and Jillian Johnston and Sarah McFarlane},
  journal={Molecular and Cellular Neuroscience},
  year={2008},
  volume={37},
  pages={247-260}
}
Transcriptional Responses of Cultured Rat Sympathetic Neurons during BMP-7-Induced Dendritic Growth
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An in vivo function for BMPs is demonstrated in the generation of mature sympathetic neuron dendrites by using a conditional knock-out strategy to eliminate Bmpr1a and Smad4 in immature noradrenergic sympathetic neurons.
Neuropilin-1 biases dendrite polarization in the retina
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It is shown in vivo that neuropilin-1 and its co-receptor plexinA1 (Plxna1) are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.
Neural activity and branching of embryonic retinal ganglion cell dendrites
Neuronal and Astroglial TGFβ-Smad3 Signaling Pathways Differentially Regulate Dendrite Growth and Synaptogenesis
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Evidence is provided for the first time that TGFβ-Smad3 signaling pathways within neuron and astrocyte differentially regulate dendrite growth and synaptogenesis, and this pathway may be involved in the pathogenesis of some central nervous system diseases, such as epilepsy.
Establishment of axon-dendrite polarity in developing neurons.
TLDR
The recent data supporting an integrative model whereby extracellular cues orchestrate the intracellular signaling underlying the initial break of neuronal symmetry leading to axon-dendrite polarization are synthesized.
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