TGFβ ligands promote the initiation of retinal ganglion cell dendrites in vitro and in vivo 

@article{Hocking2008TGFLP,
  title={TGF$\beta$ ligands promote the initiation of retinal ganglion cell dendrites in vitro and in vivo
},
  author={Jennifer C. Hocking and Carrie Lynn Hehr and Ruoh-Yeng Chang and Jillian Johnston and Sarah McFarlane},
  journal={Molecular and Cellular Neuroscience},
  year={2008},
  volume={37},
  pages={247-260}
}
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Transcriptional Responses of Cultured Rat Sympathetic Neurons during BMP-7-Induced Dendritic Growth
TLDR
This study provides a unique dataset that will be useful in generating testable hypotheses regarding transcriptional control of the initial stages of dendritic growth in naïve vs. BMP-treated sympathetic neurons and implicates both established and novel genes and signaling pathways in primary dendritogenesis.
LIMK1 acts downstream of BMP signaling in developing retinal ganglion cell axons but not dendrites.
Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development
TLDR
In vivo, the apical and basal dendritic arbours of pyramidal cells throughout the hippocampus were markedly stunted in both homozygous and heterozygous Gdf5 null mutants, indicating that dendrite size and complexity are exquisitely sensitive to the level of endogenous GDF5 synthesis.
Extrinsic factors as multifunctional regulators of retinal ganglion cell morphogenesis
TLDR
Data are discussed which argue that the visual system uses a limited number of signals to control RGC morphogenesis, with single molecules being reused multiple times to control distinct events in axon and dendrite outgrowth.
Dendrite Complexity of Sympathetic Neurons Is Controlled during Postnatal Development by BMP Signaling
TLDR
An in vivo function for BMPs is demonstrated in the generation of mature sympathetic neuron dendrites by using a conditional knock-out strategy to eliminate Bmpr1a and Smad4 in immature noradrenergic sympathetic neurons.
Neuropilin-1 biases dendrite polarization in the retina
TLDR
It is shown in vivo that neuropilin-1 and its co-receptor plexinA1 (Plxna1) are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.
Neural activity and branching of embryonic retinal ganglion cell dendrites
Distinct roles for Robo2 in the regulation of axon and dendrite growth by retinal ganglion cells
Neuronal and Astroglial TGFβ-Smad3 Signaling Pathways Differentially Regulate Dendrite Growth and Synaptogenesis
TLDR
Evidence is provided for the first time that TGFβ-Smad3 signaling pathways within neuron and astrocyte differentially regulate dendrite growth and synaptogenesis, and this pathway may be involved in the pathogenesis of some central nervous system diseases, such as epilepsy.
Establishment of axon-dendrite polarity in developing neurons.
TLDR
The recent data supporting an integrative model whereby extracellular cues orchestrate the intracellular signaling underlying the initial break of neuronal symmetry leading to axon-dendrite polarization are synthesized.
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References

SHOWING 1-10 OF 74 REFERENCES
OP-1 Enhances Dendritic Growth from Cerebral Cortical Neurons in Vitro
TLDR
It is demonstrated that OP-1 selectively increases dendrite growth from cerebral cortical neurons in vitro and was dose-dependent; maximal dendritic growth was observed after the addition of 30-100 ng/ml of OP- 1 to the culture medium.
Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons
TLDR
RT-PCR and immunocytochemical analyses indicate that BMP-5 mRNA and protein are expressed in the superior cervical ganglia (SCG) during times of initial growth and rapid expansion of the dendritic arbor, suggesting a role for B MP-5 in regulating dendrite growth in sympathetic neurons.
GABA Regulates Dendritic Growth by Stabilizing Lamellipodia in Newly Generated Interneurons of the Olfactory Bulb
TLDR
It is shown that ambient GABA acting through GABAA receptors is essential for the temporal stability of lamellipodial protrusions in dendritic growth cones but did not interfere with filopodia dynamics, and this mechanism by which this neurotransmitter drives early dendrite growth is offered.
Polarization and orientation of retinal ganglion cells in vivo
TLDR
Four-dimensional microscopy of developing retinal ganglion cells (RGCs) in live zebrafish embryos indicates that extrinsic factors such as access to the basal lamina are critical for normal axon emergence from RGCs in vivo.
Glial cells promote dendritic development in rat sympathetic neurons in vitro
TLDR
The morphology of embryonic rat sympathetic neurons grown in the absence and in the presence of ganglionic nonneuronal cells in serum‐free medium is compared to indicate that glia selectively promote dendritic development in sympathetic neurons maintained in serum-free medium.
Chimeric Integrins Expressed in Retinal Ganglion Cells Impair Process Outgrowth in Vivo
TLDR
Findings show that beta 1 integrins play an important role in regulating the outgrowth of axons and dendrites from RGCs in the retina but that chimeric integrinins do not impair growth cone steering in general.
Multiple signaling pathways regulate FGF-2-induced retinal ganglion cell neurite extension and growth cone guidance
Spinal Cord Neuronal Precursors Generate Multiple Neuronal Phenotypes in Culture
TLDR
A single neuronal precursor cell can differentiate into multiple classes of neurons, and this differentiation can be modulated by environmental signals.
Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons
Brain-Derived Neurotrophic Factor Differentially Regulates Retinal Ganglion Cell Dendritic and Axonal Arborization In Vivo
TLDR
It is shown that BDNF can differentially modulate axonal and dendritic arborization within a single neuronal population in opposing manners and raise the possibility that differential modulation by a neurotrophic factor finely tunes the morphological differentiation program of a neuron.
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