TGFβ ligands promote the initiation of retinal ganglion cell dendrites in vitro and in vivo
@article{Hocking2008TGFLP, title={TGF$\beta$ ligands promote the initiation of retinal ganglion cell dendrites in vitro and in vivo }, author={Jennifer C. Hocking and Carrie Lynn Hehr and Ruoh-Yeng Chang and Jillian Johnston and Sarah McFarlane}, journal={Molecular and Cellular Neuroscience}, year={2008}, volume={37}, pages={247-260} }
30 Citations
Transcriptional Responses of Cultured Rat Sympathetic Neurons during BMP-7-Induced Dendritic Growth
- BiologyPloS one
- 2011
This study provides a unique dataset that will be useful in generating testable hypotheses regarding transcriptional control of the initial stages of dendritic growth in naïve vs. BMP-treated sympathetic neurons and implicates both established and novel genes and signaling pathways in primary dendritogenesis.
LIMK1 acts downstream of BMP signaling in developing retinal ganglion cell axons but not dendrites.
- BiologyDevelopmental biology
- 2009
Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development
- BiologyDevelopment
- 2013
In vivo, the apical and basal dendritic arbours of pyramidal cells throughout the hippocampus were markedly stunted in both homozygous and heterozygous Gdf5 null mutants, indicating that dendrite size and complexity are exquisitely sensitive to the level of endogenous GDF5 synthesis.
Extrinsic factors as multifunctional regulators of retinal ganglion cell morphogenesis
- BiologyDevelopmental neurobiology
- 2011
Data are discussed which argue that the visual system uses a limited number of signals to control RGC morphogenesis, with single molecules being reused multiple times to control distinct events in axon and dendrite outgrowth.
Dendrite Complexity of Sympathetic Neurons Is Controlled during Postnatal Development by BMP Signaling
- BiologyThe Journal of Neuroscience
- 2013
An in vivo function for BMPs is demonstrated in the generation of mature sympathetic neuron dendrites by using a conditional knock-out strategy to eliminate Bmpr1a and Smad4 in immature noradrenergic sympathetic neurons.
Neuropilin-1 biases dendrite polarization in the retina
- BiologyDevelopment
- 2013
It is shown in vivo that neuropilin-1 and its co-receptor plexinA1 (Plxna1) are necessary to bias the extension of the dendrites of retinal ganglion cells to the apical side of the cell, and ectopically expressed class III semaphorins (Sema3s) disrupt this process.
Neural activity and branching of embryonic retinal ganglion cell dendrites
- BiologyMechanisms of Development
- 2012
Distinct roles for Robo2 in the regulation of axon and dendrite growth by retinal ganglion cells
- BiologyMechanisms of Development
- 2010
Neuronal and Astroglial TGFβ-Smad3 Signaling Pathways Differentially Regulate Dendrite Growth and Synaptogenesis
- BiologyNeuroMolecular Medicine
- 2014
Evidence is provided for the first time that TGFβ-Smad3 signaling pathways within neuron and astrocyte differentially regulate dendrite growth and synaptogenesis, and this pathway may be involved in the pathogenesis of some central nervous system diseases, such as epilepsy.
Establishment of axon-dendrite polarity in developing neurons.
- BiologyAnnual review of neuroscience
- 2009
The recent data supporting an integrative model whereby extracellular cues orchestrate the intracellular signaling underlying the initial break of neuronal symmetry leading to axon-dendrite polarization are synthesized.
References
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It is shown that BDNF can differentially modulate axonal and dendritic arborization within a single neuronal population in opposing manners and raise the possibility that differential modulation by a neurotrophic factor finely tunes the morphological differentiation program of a neuron.