TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy.

  title={TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy.},
  author={J. Martijn Bos and Malayannan Subramaniam and John R Hawse and Imke Christiaans and Nalini M. Rajamannan and Joseph John Maleszewski and William D. Edwards and Arthur A. M. Wilde and Thomas C. Spelsberg and Michael J. Ackerman},
  journal={Journal of cellular biochemistry},
  volume={113 6},
Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disease. A recent study showed that male KLF10-encoded TGFβ Inducible Early Gene-1 knock-out mice (TIEG-/-) develop HCM with 13-fold up-regulation of PTTG1-encoded pituitary tumor-transforming gene 1. We hypothesized TIEG1 could be a novel candidate gene in the pathogenesis of… CONTINUE READING