TGFβ and PDGF-B signaling blockade inhibits myofibroblast development from both bone marrow-derived and keratocyte-derived precursor cells in vivo.

@article{Singh2014TGFAP,
  title={TGFβ and PDGF-B signaling blockade inhibits myofibroblast development from both bone marrow-derived and keratocyte-derived precursor cells in vivo.},
  author={Vivek Singh and Ritika Jaini and Andr{\'e} Augusto Miranda Torricelli and Marcony Rodrigues de Santhiago and Nirbhai Singh and Bala K Ambati and Steven E Wilson},
  journal={Experimental eye research},
  year={2014},
  volume={121},
  pages={35-40}
}
Myofibroblasts, the primary cells associated with corneal stromal haze (opacity), can be derived from both cornea-derived and bone marrow-derived precursor cells. In the present study, the role of TGFβ or PDGF blockage on bone marrow-derived myofibroblast development was investigated using a green fluorescent protein (GFP) chimeric bone marrow mouse model and plasmid vectors that blocked TGFβ or PDGF signaling. At the peak of corneal haze one month after irregular phototherapeutic keratectomy… CONTINUE READING
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