TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease

@article{Sartori2014TGFAB,
  title={TGF$\beta$ and BMP signaling in skeletal muscle: potential significance for muscle-related disease},
  author={R. Sartori and P. Gregorevic and M. Sandri},
  journal={Trends in Endocrinology \& Metabolism},
  year={2014},
  volume={25},
  pages={464-471}
}
The transforming growth factor beta (TGFβ) superfamily comprises a large number of secreted proteins that regulate various fundamental biological processes underlying embryonic development and the postnatal regulation of many cell types and organs. Sequence similarities define two ligand subfamilies: the TGFβ/activin subfamily and the bone morphogenetic protein (BMP) subfamily. The discovery that myostatin, a member of the TGFβ/activin subfamily, negatively controls muscle mass attracted… Expand
Bone and morphogenetic protein signalling and muscle mass
  • R. Sartori, M. Sandri
  • Biology, Medicine
  • Current opinion in clinical nutrition and metabolic care
  • 2015
TLDR
The rapid progress made in the last year regarding the signalling downstream TGF&bgr; superfamily and its involvement in the homeostasis of adult muscle fibres is reviewed. Expand
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TLDR
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BMP signaling controls postnatal muscle development.
TLDR
It is demonstrated that BMPs are essential growth factors for postnatal skeletal muscle and its presence is indispensable for muscle tissue maintenance. Expand
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TLDR
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TLDR
New developments in the field of BMP and BMP antagonist biology during mammalian development are reviewed and strategies for targeting these proteins in human disease are suggested. Expand
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TLDR
In this review, the available information on BMP signaling in adipose tissue is summarized using preferentially articles that have appeared in the last decade, which together demonstrate the importance of BMP signalling in adiposes biology. Expand
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TLDR
The role of BMP receptor signaling is discussed and how corruption of this pathway contributes to cardiovascular and musculoskeletal diseases and cancer is discussed. Expand
Activin A more prominently regulates muscle mass in primates than does GDF8
TLDR
It is suggested that inhibition of both ligands provides a preferred therapeutic approach, which maximizes the benefit:risk ratio for muscle diseases in man, and identifies activin A as a second negative regulator of muscle mass. Expand
Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair
TLDR
It is shown that two TGF-β family members, Mstnb and Inhbaa, have opposite effects in regeneration, with mstnb overexpression or inhbaa loss-of-function causing cardiac scarring after injury. Expand
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