TGFβ-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion

Abstract

Transforming growth factor-β (TGFβ) promotes glomerular hypertrophy and matrix expansion, leading to glomerulosclerosis. MicroRNAs are well suited to promote fibrosis because they can repress gene expression, which negatively regulate the fibrotic process. Recent cellular and animal studies have revealed enhanced expression of microRNA, miR-21, in renal… (More)
DOI: 10.1371/journal.pone.0042316

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@inproceedings{Dey2012TGFStimulatedMU, title={TGFβ-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion}, author={Nirmalya Dey and Nandini Ghosh-Choudhury and Balakuntalam S Kasinath and Goutam Ghosh Choudhury}, booktitle={PloS one}, year={2012} }