TGFβ/SMAD/microRNA-486-3p Signaling Axis Mediates Keratin 17 Expression and Keratinocyte Hyperproliferation in Psoriasis.

Abstract

Keratin 17 (K17) is strongly expressed in psoriatic lesions but not healthy skin, and plays a crucial role in disease pathogenesis. The mechanism of aberrant K17 expression in psoriasis has not been fully elucidated. MicroRNAs are short, single-stranded, noncoding RNAs that play important roles in regulating gene expression. Psoriasis exhibits a specific… (More)
DOI: 10.1016/j.jid.2017.06.005

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Cite this paper

@article{Jiang2017TGFSMADmicroRNA4863pSA, title={TGFβ/SMAD/microRNA-486-3p Signaling Axis Mediates Keratin 17 Expression and Keratinocyte Hyperproliferation in Psoriasis.}, author={Man Jiang and Zhongbin Sun and Erle Dang and Bing Li and Hui Fang and Junqin Li and Lin Gao and Kaiming Zhang and Gang Wang}, journal={The Journal of investigative dermatology}, year={2017}, volume={137 10}, pages={2177-2186} }