TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress

@inproceedings{GmezHerreros2012TFIISIR,
  title={TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress},
  author={Fernando G{\'o}mez-Herreros and Lola de Miguel-Jim{\'e}nez and Macarena Morillo-Huesca and Lidia Delgado-Ramos and Mar{\'i}a de la Cruz Mu{\~n}oz-Centeno and Sebasti{\'a}n Ch{\'a}vez},
  booktitle={Nucleic acids research},
  year={2012}
}
Transcription factor IIS (TFIIS) stimulates RNA cleavage by RNA polymerase II by allowing backtracked enzymes to resume transcription elongation. Yeast cells do not require TFIIS for viability, unless they suffer severe transcriptional stress due to NTP-depleting drugs like 6-azauracil or mycophenolic acid. In order to broaden our knowledge on the role of TFIIS under transcriptional stress, we carried out a genetic screening for suppressors of TFIIS-lacking cells' sensitivity to 6-azauracil and… CONTINUE READING
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