TFIIIC binding sites function as both heterochromatin barriers and chromatin insulators in Saccharomyces cerevisiae.

@article{Simms2008TFIIICBS,
  title={TFIIIC binding sites function as both heterochromatin barriers and chromatin insulators in Saccharomyces cerevisiae.},
  author={Tiffany A. Simms and Sandra L. Dugas and Jason C Gremillion and Megan E. Ibos and M Nicole Dandurand and Tasha T Toliver and Daniel J. Edwards and David Donze},
  journal={Eukaryotic cell},
  year={2008},
  volume={7 12},
  pages={2078-86}
}
Chromosomal sites of RNA polymerase III (Pol III) transcription have been demonstrated to have "extratranscriptional" functions, as the assembled Pol III complex can act as chromatin boundaries or pause sites for replication forks, can alter nucleosome positioning or affect transcription of neighboring genes, and can play a role in sister chromatid cohesion. Several studies have demonstrated that assembled Pol III complexes block the propagation of heterochromatin-mediated gene repression. Here… CONTINUE READING
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