TFF2-CXCR4 Axis Is Associated with BRAF V600E Colon Cancer.

Abstract

Oncogene-induced senescence (OIS), a tumor-suppressive mechanism that is induced by the replicative and metabolic stress of oncogene activation, is a key barrier in the development of BRAF V600E colon cancer. Inhibition of this mechanism has been observed through epigenetic changes observed in sporadic serrated polyps, as well as through the germline… (More)
DOI: 10.1158/1940-6207.CAPR-14-0444

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