TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines.

@article{Siu2004TFF2F,
  title={TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines.},
  author={Lai-San Siu and Hanna Romanska and Paul David Abel and Mirela Baus-Lon{\vc}ar and Tuncay Kayademir and Gordon Stamp and E. -N. Lalani},
  journal={Peptides},
  year={2004},
  volume={25 5},
  pages={855-63}
}
We have recently demonstrated that human TFF2 inhibits apoptosis in the non-TFF2 expressing breast adenocarcinoma cell line MCF-7. In this study we examined the impact of TFF2 and an anti-TFF2 antibody (hSP3) on the survival of other human adenocarcinoma cell lines; TFF2-positive (LS174T and SW480) and TFF2-negative (MCF-7 and T47D). Addition of TFF2 protected the (TFF2-) lines but had no effect on those constitutively expressing TFF2. Blocking with hSP3 significantly increased apoptosis in the… CONTINUE READING