TFF1 activates p53 through down-regulation of miR-504 in gastric cancer

  title={TFF1 activates p53 through down-regulation of miR-504 in gastric cancer},
  author={Mohammed Soutto and Zheng Chen and Mohamed Al Sayed Saleh and Ahmed M Katsha and Shoumin Zhu and Alexander I. Zaika and A. Belkhiri and Wael El-Rifai},
The expression of TFF1 is frequently down-regulated in human gastric cancer whereas its knockout leads to the development of gastric adenomas and carcinomas in mouse models. The molecular mechanisms underlying the TFF1 tumor suppressor functions remain unclear. In this study, we demonstrate, using colony formation assay and Annexin V staining, that reconstitution of TFF1 expression in gastric cancer cell models suppresses cell growth and promotes cell death. Furthermore, using a tumor xenograft… CONTINUE READING


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