• DOI:10.1038/s41467-017-01871-z
Corpus ID: 3309194

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

@article{Willett2017TFEBRL,
  title={TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes},
  author={R. Willett and J. Martina and James P Zewe and Rachel C Wills and Gerald R V Hammond and R. Puertollano},
  journal={Nature Communications},
  year={2017},
  volume={8}
}

R. Willett, J. Martina, +3 authors R. Puertollano

Published 2017

Chemistry, Medicine

Nature Communications

Lysosomal distribution is linked to the role of lysosomes in many cellular functions, including autophagosome degradation, cholesterol homeostasis, antigen presentation, and cell invasion. Alterations in lysosomal positioning contribute to different human pathologies, such as cancer, neurodegeneration, and lysosomal storage diseases. Here we report the identification of a novel mechanism of lysosomal trafficking regulation. We found that the lysosomal transmembrane protein TMEM55B recruits JIP4… CONTINUE READING

View on Springer

nature.com

Save to Library

Create Alert

Cite

Launch Research Feed