TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

  title={TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes},
  author={R. Willett and J. Martina and James P Zewe and Rachel C Wills and Gerald R V Hammond and R. Puertollano},
  journal={Nature Communications},
  • R. Willett, J. Martina, +3 authors R. Puertollano
  • Published 2017
  • Chemistry, Medicine
  • Nature Communications
  • Lysosomal distribution is linked to the role of lysosomes in many cellular functions, including autophagosome degradation, cholesterol homeostasis, antigen presentation, and cell invasion. Alterations in lysosomal positioning contribute to different human pathologies, such as cancer, neurodegeneration, and lysosomal storage diseases. Here we report the identification of a novel mechanism of lysosomal trafficking regulation. We found that the lysosomal transmembrane protein TMEM55B recruits JIP4… CONTINUE READING
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