TFBS identification by position- and consensus-led genetic algorithm with local filtering

@inproceedings{Chan2007TFBSIB,
  title={TFBS identification by position- and consensus-led genetic algorithm with local filtering},
  author={Tak-Ming Chan and Kwong-Sak Leung and Kin-Hong Lee},
  booktitle={GECCO},
  year={2007}
}
Identification of Transcription Factor Binding Site (TFBS) motifs in multiple DNA upstream sequences is important in understanding the mechanism of gene regulation. This identification problem is challenging because such motifs are usually weakly conserved due to evolutionary variation. Exhaustive search is intractable for finding long motifs because the combinatorial growth of the search space is exponential, thus heuristic methods are preferred. In this paper, we propose the Genetic Algorithm… CONTINUE READING

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