TFAM detects co-evolution of tRNA identity rules with lateral transfer of histidyl-tRNA synthetase

@article{Ardell2006TFAMDC,
  title={TFAM detects co-evolution of tRNA identity rules with lateral transfer of histidyl-tRNA synthetase},
  author={David H. Ardell and Siv G. E. Andersson},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={893 - 904}
}
We present TFAM, an automated, statistical method to classify the identity of tRNAs. TFAM, currently optimized for bacteria, classifies initiator tRNAs and predicts the charging identity of both typical and atypical tRNAs such as suppressors with high confidence. We show statistical evidence for extensive variation in tRNA identity determinants among bacterial genomes due to variation in overall tDNA base content. With TFAM we have detected the first case of eukaryotic-like tRNA identity rules… CONTINUE READING

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