TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis.

@article{Quivoron2011TET2IR,
  title={TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis.},
  author={Cyril Quivoron and Lucile Couronn{\'e} and V{\'e}ronique Della Valle and C{\'e}cile K. Lopez and Isabelle Plo and Orianne Wagner-Ballon and Marcio Do Cruzeiro and François Delhommeau and Bertrand Arnulf and Marc-Henri Stern and Lucy A Godley and Paule Opolon and Herv{\'e} Tilly and {\'E}ric Solary and Yannis Duffourd and Philippe Dessen and H{\'e}l{\`e}ne Merle-B{\'e}ral and Florence Nguyen-Khac and Micha{\"e}la Fontenay and William Vainchenker and Christian Bastard and Thomas Mercher and Olivier Adrien Bernard},
  journal={Cancer cell},
  year={2011},
  volume={20 1},
  pages={25-38}
}
Loss-of-function mutations affecting one or both copies of the Ten-Eleven-translocation (TET)2 gene have been described in various human myeloid malignancies. We report that inactivation of Tet2 in mouse perturbs both early and late steps of hematopoiesis including myeloid and lymphoid differentiation in a cell-autonomous manner, endows the cells with competitive advantage, and eventually leads to the development of malignancies. We subsequently observed TET2 mutations in human lymphoid… CONTINUE READING
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