TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

@inproceedings{Deplus2013TET2AT,
  title={TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS},
  author={Rachel Deplus and Benjamin Delatte and Marie K Schwinn and Matthieu Defrance and Jacqui M{\'e}ndez and N. Murphy and Mark A Dawson and Michael Volkmar and Pascale Putmans and Emilie Calonne and Alan H. Shih and Ross L. Levine and Olivier Adrien Bernard and Thomas Mercher and {\'E}ric Solary and Marjeta Urh and Danette L Daniels and François Fuks},
  booktitle={The EMBO journal},
  year={2013}
}
TET proteins convert 5-methylcytosine to 5-hydroxymethylcytosine, an emerging dynamic epigenetic state of DNA that can influence transcription. Evidence has linked TET1 function to epigenetic repression complexes, yet mechanistic information, especially for the TET2 and TET3 proteins, remains limited. Here, we show a direct interaction of TET2 and TET3 with O-GlcNAc transferase (OGT). OGT does not appear to influence hmC activity, rather TET2 and TET3 promote OGT activity. TET2/3-OGT co… CONTINUE READING
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