TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.

@article{Montagner2016TET2RM,
  title={TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.},
  author={Sara Montagner and Cristina Leoni and Stefan Emming and Giulia Della Chiara and Chiara Balestrieri and Iros Barozzi and Viviana Piccolo and Susan M. Togher and Myunggon Ko and Anjana Rao and Gioacchino Natoli and Silvia Monticelli},
  journal={Cell reports},
  year={2016},
  volume={15 7},
  pages={
          1566-1579
        }
}
Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2 as a crucial regulator of mast cell differentiation and proliferation. In the absence of TET2, mast cells showed disrupted gene expression and altered genome-wide 5hmC deposition, especially at enhancers and in the proximity of downregulated genes. Impaired differentiation of Tet2-ablated cells could be relieved or further exacerbated by… CONTINUE READING
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