TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases.

Abstract

Tumor suppressor gene silencing through cytosine methylation contributes to cancer formation. Whether DNA demethylation enzymes counteract this oncogenic effect is unknown. Here, we show that TET1, a dioxygenase involved in cytosine demethylation, is downregulated in prostate and breast cancer tissues. TET1 depletion facilitates cell invasion, tumor growth… (More)
DOI: 10.1016/j.celrep.2012.08.030

Topics

7 Figures and Tables