TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway

Abstract

Ten eleven translocation (TET) enzymes catalyse the oxidative reactions of 5-methylcytosine (5mC) to promote the demethylation process. The reaction intermediate 5-hydroxymethylcytosine (5hmC) has been shown to be abundant in embryonic stem cells and tissues but strongly depleted in human cancers. Genetic mutations of TET2 gene were associated with… (More)
DOI: 10.1038/onc.2014.356

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@article{Neri2015TET1IA, title={TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway}, author={Fidencio V Neri and Daniela Dettori and Domenico Incarnato and Ad{\'e}la Křepelov{\'a} and Stefania Rapelli and Mara Maldotti and Caterina Parlato and Panagiotis Paliogiannis and Salvatore Oliviero}, journal={Oncogene}, year={2015}, volume={34}, pages={4168-4176} }